4 15 16 29 30 Some studies adjusted the untreated population2012.04.02

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pandora earrings There were no randomised controlled studies. Three studies examined the impact of cold knife conisation on the studied outcomes,14 24 27 six on large loop excision of the transformation zone (LLETZ),13 23 25 26 31 32 one on laser conisation,28 and the remaining five on multiple treatment techniques.4 15 16 29 30 Some studies adjusted the untreated population for known risk factors for adverse reproductive outcomes,13 14 23 25 31 some included women with cervical intraepithelial neoplasia who received no treatment,32 some did not match for any confounders,26 others used internal controls (outcomes in the same women before and after treatment),24 27 28 30 whereas some performed a logistic regression to control for known confounders.4 15 16 29 Two of the studies using internal controls also matched for known confounders such as age and parity.27 30 The data were retrieved from hospital records, questionnaires, and national registries. The number of participants in the treated and untreated groups ranged from 21 to 15108 and from 20 to 2164006, respectively (table 1).Table 1 Characteristics of included studies comparing fertility and early pregnancy outcomes with untreated womenView this table:View popupView inlineTable 1 shows the Newcastle Ottawa scores for quality assessment of the observational studies pandora earrings.